Acurx Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2023 Results and Provides Business Update
- Positive Phase 2b clinical trial results for ibezapolstat with a 96% clinical cure rate
- Submission of data to the FDA for an End of Phase 2 Meeting
- SME designation from the EMA for benefits in seeking Marketing Authorization for Europe
- Presentation at ID Week on selective spectrum of activity data and novel DNA pol IIIC inhibitors
- Launch of a $17 million ATM equity offering program for general corporate purposes including Phase 3 clinical trial mandate
- Decrease in cash position from $9.1 million to $7.5 million
- Increased R&D and G&A expenses for the quarter and year
- Net loss of $5.1 million for the quarter and $14.6 million for the year
Insights
The financial results of Acurx Pharmaceuticals reflect a strategic allocation of resources towards the development of ibezapolstat, their lead antibiotic candidate. The increase in R&D expenses, from $1.4 million to $1.9 million quarterly and from $4.8 million to $6.0 million annually, signifies a focused investment in the Phase 2b clinical trial. This decision is presumably based on the promising clinical cure rates reported, which could potentially lead to a significant market advantage if the drug is approved. The ATM financing program, generating $4.5 million post-year-end, suggests a proactive approach to funding their Phase 3 trials without immediate dilution of shareholder value.
However, the increased G&A expenses, which rose from $1.8 million to $3.2 million quarterly, indicate higher operational costs that could affect the company's burn rate. The net loss widening from $3.3 million to $5.1 million quarterly and from $12.1 million to $14.6 million annually, may raise concerns among investors regarding the sustainability of current spending levels, especially if additional financing is required before ibezapolstat generates revenue.
The clinical data for ibezapolstat is noteworthy, with a 96% cure rate at EOT and no reported safety concerns. The early termination of the Phase 2b trial due to success is a positive indicator, yet it is essential to scrutinize the robustness of the data, considering the relatively small sample size. The sustained cure rate and microbiome data further differentiate ibezapolstat from vancomycin, potentially positioning it as a superior treatment for CDI.
The impact on the microbiome is particularly significant as it suggests a reduced likelihood of CDI recurrence, a major issue with current treatments. The anticipation of more detailed data from secondary endpoints could further solidify ibezapolstat's profile. Nevertheless, the true commercial potential will hinge on Phase 3 results, regulatory approval and the ability to capture market share from established treatments.
The designation as an SME by the EMA is a strategic milestone for Acurx, offering financial and regulatory support for market authorization in Europe. This could expedite the drug's approval process and reduce costs, enhancing the company's market entry strategy. The ATM offering's success indicates investor confidence in the company's prospects and provides necessary capital for upcoming trials.
Looking ahead, the market for CDI treatments is competitive but also ripe for innovation, especially for antibiotics that can prevent recurrence. Acurx's positioning of ibezapolstat, with its promising clinical data, could disrupt the current treatment paradigm if the Phase 3 trials confirm its efficacy and safety profile. Investors will likely monitor the FDA's feedback post-Phase 2 meeting and the subsequent Phase 3 trial design for further indications of the drug's potential impact on the market.
Highlights of the fourth quarter ended December 31, 2023, or in some cases shortly thereafter, include:
- In October 2023, we ended enrollment in our Phase 2b clinical trial of ibezapolstat, our lead antibiotic candidate, for the treatment of patients with C. difficile infection, or CDI.
- In November 2023, we reported top-line data from the Phase 2b clinical trial, including overall results from the full Phase 2 study, demonstrating an ibezapolstat clinical cure rate at end of 10-days' oral treatment, or EOT, of
96% (25 of 26 patients) which included100% cure in Phase 2a (10 of 10 patients) and94% in Phase 2b (15 of 16 patients) compared with the vancomycin control arm of100% (14 of 14 patients) at EOT. No safety concerns were reported in either arm of the Phase 2b clinical trial and ibezapolstat was well tolerated in all patients in both the Phase 2a open label trial and in the Phase 2b vancomycin-controlled segment. In consultation with its scientific advisors, the Company determined that based on review of aggregate blinded data the Phase 2b vancomycin-controlled trial segment was terminated early due to success showing high observed clinical cure rates with no emerging safety concerns. We also stated at that further data would be provided as they become available on secondary and exploratory endpoints from the Phase 2b trial segment, including sustained clinical cure data at 30 days after EOT, and Extended Clinical cure data up to 94 days as well as comparative data on the impact to the patient's microbiome. - In December 2023, we announced the sustained clinical cure data. These data showed that in the Phase 2b clinical trial segment
100% or 15 out of 15 patients who were cured at EOT remained cured with no reinfection 30 days later while vancomycin experienced a reinfection rate of14.3% (2 of 14 patients). - In January 2024, the Company announced positive comparative microbiology and microbiome data for ibezapolstat in CDI patients from the Phase 2b clinical trial segment. Ibezapolstat outperformed vancomycin showing eradication of fecal C. difficile at Day 3 of treatment in 15 of 16 treated patients (
94% ), versus vancomycin which had eradication of C. difficile in 10 of 14 treated patients (71% ). Additional data from this Phase 2b clinical trial showed ibezapolstat, but not vancomycin, consistently preserved and allowed regrowth of key gut bacterial species believed to confer health benefits including to prevent recurrence of CDI. - The Company anticipates that additional data from the secondary and exploratory endpoints will provide further favorable separation between these two therapeutic options in our Phase 3 clinical trial program and ultimately in the marketplace, if approved. Additional analyses regarding other secondary and exploratory endpoints will be forthcoming as data become available.
- Having robust preclinical, clinical and manufacturing data-to-date, the Company submitted a formidable Information Package to FDA in February 2024 along with a Request for an End of Phase 2 Meeting which was granted by the FDA and is scheduled to occur in April. We anticipate discussing our Phase 3 clinical trial mandate at this meeting and would anticipate documented meeting minutes from FDA in the second quarter of 2024.
- The European Medicines Agency (or EMA) approved our application to be designated as a small to medium sized enterprise (or SME) in
Europe in February 2024 which provides for certain benefits including fee reductions and other support from the EMA for seeking a Marketing Authorization forEurope . - In October 2023, Dr. Kevin Garey presented on behalf of the Company at ID Week with selective spectrum of activity data from our Phase 2a clinical trial. Dr. Garey is Professor and Chair, University of
Houston College of Pharmacy, and the Principal Investigator for microbiome aspects of our ibezapolstat clinical trial program. Also at ID Week, Bob DeLuccia, our Executive Chairman, presented our new class of novel DNA pol IIIC inhibitors in our pre-clinical pipeline at the symposium entitled, "New Antimicrobials in the Pipeline." - In November 2023, the Company filed an amendment to its shelf registration statement with the SEC and launched a
at-the-market equity offering program (or ATM), with Alliance Global Partners acting as sales agent to the Company. Proceeds from the ATM have been and, in the future, are expect to be used for general corporate purposes going forward including our planned Phase 3 clinical trial mandate.$17 million
Fourth Quarter and Full Year 2023 Financial Results
- Cash Position:
The Company ended the year with cash totaling , compared to$7.5 million as of December 31, 2022. Subsequent to year-end, the Company sold an additional 1,121,793 shares under its ATM financing program, with gross proceeds of approximately$9.1 million .$4.5 million
- R&D Expenses:
Research and development expenses for the three months ended December 31, 2023 were compared to$1.9 million for the three months ended December 31, 2022. The increase was due to the timing of Phase 2b trial related costs and an increase in consulting costs. For the year ended December 31, 2023, research and development expenses were$1.4 million versus$6.0 million for the year ended December 31, 2022. The increase is due primarily to Phase 2b trial-related costs and an increase in consulting costs.$4.8 million
- G&A Expenses:
General and administrative expenses for the three months ended December 31, 2023 were compared to$3.2 million for the three months ended December 31, 2022. The increase was due primarily to a$1.8 million increase in professional fees, a$0.8 million increase in share-based compensation, and a$0.1 million increase in employee compensation costs. For the year ended December 31, 2023, general and administrative expenses were$0.3 million versus$8.5 million for the year ended December 31, 2022. The amounts reflect an increase in professional fees of$7.3 million , an increase of$0.5 million in share-based compensation, and an increase of$0.3 million in employee compensation costs.$0.3 million
- Net Income/Loss:
The Company reported a net loss of or$5.1 million per diluted share for the three months ended December 31, 2023 compared to a net loss of$0.37 or$3.3 million per diluted share for the three months ended December 31, 2022, and a net loss of$0.28 or$14.6 million per share for the year ended December 31, 2023, compared to a net loss of$1.15 or$12.1 million per diluted share for the year ended December 31, 2022 for the reasons previously mentioned.$1.12
The Company had 14,468,229 shares outstanding as of December 31, 2023.
Conference Call
As previously announced, David P. Luci, President and Chief Executive Officer, and Robert G. Shawah, Chief Financial Officer, will host a conference call to discuss the results and provide a business update as follows:
Date: | Monday, March 18, 2024 |
Time: | 8:00 a.m. ET |
Toll free ( | 877-790-1503 |
Conference ID: | 13744881 |
About Ibezapolstat
Ibezapolstat is the Company's lead antibiotic candidate advancing to international Phase 3 clinical trials to treat patients with C. difficile Infection (CDI). Ibezapolstat is a novel, orally administered antibiotic being developed as a Gram-Positive Selective Spectrum (GPSS®) antibacterial. It is the first of a new class of DNA polymerase IIIC inhibitors under development by Acurx to treat bacterial infections. Ibezapolstat's unique spectrum of activity, which includes C. difficile but spares other Firmicutes and the important Actinobacteria phyla, appears to contribute to the maintenance of a healthy gut microbiome.
In June 2018, ibezapolstat was designated by the
About Acurx Pharmaceuticals, Inc.
Acurx Pharmaceuticals is a late-stage biopharmaceutical company focused on developing a new class of small molecule antibiotics for difficult-to-treat bacterial infections. The Company's approach is to develop antibiotic candidates with a Gram-positive selective spectrum (GPSS®) that blocks the active site of the Gram+ specific bacterial enzyme DNA polymerase IIIC (pol IIIC), inhibiting DNA replication and leading to Gram-positive bacterial cell death. Its R&D pipeline includes antibiotic product candidates that target Gram-positive bacteria, including Clostridioides difficile, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin resistant Enterococcus (VRE) and drug-resistant Streptococcus pneumoniae (DRSP).
To learn more about Acurx Pharmaceuticals and its product pipeline, please visit www.acurxpharma.com.
Forward-Looking Statements
Any statements in this press release about our future expectations, plans and prospects, including statements regarding our strategy, future operations, prospects, plans and objectives, and other statements containing the words "believes," "anticipates," "plans," "expects," and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: whether ibezapolstat will benefit from the QIDP designation; whether ibezapolstat will advance through the clinical trial process on a timely basis; whether the results of the clinical trials of ibezapolstat will warrant the submission of applications for marketing approval, and if so, whether ibezapolstat will receive approval from the FDA or equivalent foreign regulatory agencies where approval is sought; whether, if ibezapolstat obtains approval, it will be successfully distributed and marketed; and other risks and uncertainties described in the Company's annual report filed with the Securities and Exchange Commission on Form 10-K for the year ended December 31, 2023, and in the Company's subsequent filings with the Securities and Exchange Commission. Such forward-looking statements speak only as of the date of this press release, and Acurx disclaims any intent or obligation to update these forward-looking statements to reflect events or circumstances after the date of such statements, except as may be required by law.
Investor Contact:
Acurx Pharmaceuticals, Inc.
David P. Luci, President & Chief Executive Officer
Tel: 917-533-1469
Email: davidluci@acurxpharma.com
ACURX PHARMACEUTICALS, INC. | ||||||
December 31, | December 31, | |||||
2023 | 2022 | |||||
ASSETS | ||||||
CURRENT ASSETS | ||||||
Cash | $ | 7,474,188 | $ | 9,111,751 | ||
Other Receivable | 129,159 | — | ||||
Prepaid Expenses | 105,776 | 264,955 | ||||
TOTAL ASSETS | $ | 7,709,123 | $ | 9,376,706 | ||
LIABILITIES AND SHAREHOLDERS' EQUITY | ||||||
CURRENT LIABILITIES | ||||||
Accounts Payable and Accrued Expenses | $ | 3,042,438 | $ | 2,061,685 | ||
TOTAL CURRENT LIABILITIES | 3,042,438 | 2,061,685 | ||||
TOTAL LIABILITIES | 3,042,438 | 2,061,685 | ||||
COMMITMENTS AND CONTINGENCIES | ||||||
SHAREHOLDERS' EQUITY | ||||||
Common Stock; | 14,468 | 11,628 | ||||
Additional Paid-In Capital | 57,871,070 | 45,944,478 | ||||
Accumulated Deficit | (53,218,853) | (38,641,085) | ||||
TOTAL SHAREHOLDERS' EQUITY | 4,666,685 | 7,315,021 | ||||
TOTAL LIABILITIES AND SHAREHOLDERS' EQUITY | $ | 7,709,123 | $ | 9,376,706 |
ACURX PHARMACEUTICALS, INC. | ||||||
Years Ended | ||||||
December 31, | ||||||
2023 | 2022 | |||||
OPERATING EXPENSES | ||||||
Research and Development | $ | 6,043,597 | $ | 4,754,271 | ||
General and Administrative | 8,534,171 | 7,338,505 | ||||
TOTAL OPERATING EXPENSES | 14,577,768 | 12,092,776 | ||||
NET LOSS | $ | (14,577,768) | $ | (12,092,776) | ||
LOSS PER SHARE | ||||||
Basic and diluted net loss per common share | $ | (1.15) | $ | (1.12) | ||
Weighted average common shares outstanding, basic and diluted | 12,671,572 | 10,816,412 |
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SOURCE Acurx Pharmaceuticals, Inc.
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