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AC Immune SA (NASDAQ: ACIU) is a clinical-stage biopharmaceutical company headquartered in Lausanne, Switzerland, committed to pioneering precision medicine for neurodegenerative diseases. The company specializes in designing, discovering, and developing innovative therapeutic and diagnostic products aimed at preventing and modifying diseases caused by misfolded proteins. Utilizing its two proprietary technology platforms, SupraAntigen® and Morphomer®, AC Immune develops a broad spectrum of antibodies, small molecules, and vaccines targeting conditions such as Alzheimer’s disease (AD), Parkinson’s disease, and NeuroOrphan indications.
With a robust pipeline consisting of sixteen therapeutic and diagnostic programs, AC Immune currently has six product candidates in clinical trials, including five in Phase 2 and one in Phase 3. The most advanced candidate, Crenezumab, is a humanized anti-amyloid-β monoclonal antibody in Phase 3 trials aimed at treating Alzheimer’s disease. Other notable candidates include ACI-24.060, a promising anti-Abeta active immunotherapy for AD and Down syndrome, which has received FDA Fast Track Designation, and ACI-35.030, an anti-pTau active immunotherapy in Phase 2b trials for preclinical AD conducted by Janssen Pharmaceuticals.
Beyond its rich pipeline, AC Immune is known for its strategic partnerships with leading global pharmaceutical companies such as Genentech (a Roche Group member), Eli Lilly and Company, and Takeda. These collaborations have resulted in significant non-dilutive funding and milestone payments totaling over $4.5 billion.
AC Immune recently secured an exclusive option and license agreement with Takeda for its ACI-24.060 product, potentially worth $2.1 billion, and completed a $50 million equity financing to support its operations into 2026. The company's focused efforts on precision prevention are reinforced by its ongoing Phase 2 trials and collaborations aimed at leveraging advanced diagnostic techniques like PET imaging and novel therapeutic approaches for early and effective intervention in neurodegenerative diseases.
AC Immune SA (NASDAQ: ACIU) announced its participation in the B.Riley Annual Neuro & Ophthalmology Virtual Investor Conference on April 27-28, 2022. CEO Prof. Andrea Pfeifer will host a Fireside chat on April 28 at 11:30 am EDT, discussing the company's development pipeline for neurodegenerative diseases and upcoming clinical milestones. Having achieved two milestones in Q1, AC Immune will present five more data readouts this year, highlighting its precision medicine approach. The webcast will be available on the company's website.
AC Immune SA (NASDAQ: ACIU) announces significant management changes, appointing Howard Donovan as Chief HR Officer and promoting Chris Roberts to Interim CFO, due to Joerg Hornstein's departure. Donovan brings extensive HR experience from the World Economic Forum, while Roberts has a strong finance background, essential for AC Immune's financial operations. Julian Snow is also promoted to Vice President, U.S. Finance & Corporate Development. The changes aim to strengthen the company's internal functions as it continues to develop precision medicine for neurodegenerative diseases.
AC Immune SA (NASDAQ: ACIU) announced the clinical validation of its a-syn PET tracer, ACI-12589, which distinguishes multiple system atrophy (MSA) from other a-synucleinopathies. This groundbreaking development, presented by Dr. Oskar Hansson, shows ACI-12589's potential in enabling targeted therapeutics and diagnostics for neurodegenerative diseases. With two validated technology platforms and a robust pipeline, AC Immune aims to accelerate therapeutic development. The company expects seven clinical data readouts in 2022, highlighting its commitment to precision medicine.
AC Immune reported significant progress in its clinical pipeline for neurodegenerative diseases, highlighting seven expected clinical data readouts in 2022. The company has advanced three vaccines targeting Tau, Abeta, and alpha-synuclein. Financially, AC Immune boasts a robust cash position of CHF 198.2 million, ensuring operations through Q1 2024. The net loss for 2021 increased to CHF 73.0 million from CHF 61.9 million in 2020. Moreover, the company anticipates total cash burn between CHF 75 million and CHF 80 million for 2022.
AC Immune SA (NASDAQ: ACIU) will host a webinar on March 29 at 10:00 AM ET to discuss alpha-synuclein in neurodegenerative diseases. KOL Oskar Hansson, MD, PhD, from Skåne University Hospital, will present the significance of biomarkers in Alzheimer’s and alpha-synucleinopathies, alongside AC Immune's clinical data on their PET tracer. The company will also outline its a-syn targeted therapeutic and diagnostic candidates, advancing precision medicine for diseases like Parkinson's. A Q&A session will follow the presentation.
AC Immune SA (NASDAQ: ACIU) announced positive proof-of-concept data for its experimental a-syn PET tracer, ACI-12589, in diagnosing Multiple System Atrophy (MSA). Conducted by Lund University, the trial showcased the ability to distinguish MSA patients from healthy individuals and other a-synucleinopathies. Dr. Oskar Hansson highlighted the breakthrough as a significant clinical advancement. The results were presented at the AD/PD Conference in Barcelona and indicate enhanced specificity and target engagement. A webinar on March 29 will further discuss these findings.
AC Immune (NASDAQ: ACIU) announced five data presentations at the International Conference on Alzheimer’s & Parkinson’s Diseases (AD/PDTM) from March 15-20, 2022, showcasing its focus on neurodegenerative diseases. Prof. Andrea Pfeifer, CEO, highlighted a significant milestone: the first in-human study of the ACI-12589 a-syn PET tracer. This research aims to enhance disease detection and prevention strategies through precision medicine. These presentations underline the company's commitment to advancing treatments for neurodegenerative diseases, potentially impacting future market performance.
AC Immune SA (NASDAQ: ACIU) revealed new interim data from its Phase 1b/2a trial for ACI-35.030, a pioneering pTau vaccine for early Alzheimer's disease. Findings show significant antibody induction specific to pathological pTau, with a favorable safety profile noted in all dosage cohorts. The study has been expanded to 24 participants to gather more data. CEO Andrea Pfeifer stated these results support ongoing late-stage development, potentially reshaping AD treatment towards earlier interventions alongside advanced diagnostics.
AC Immune SA (NASDAQ: ACIU) announced strong preclinical results for its optimized ACI-24 vaccine targeting neurotoxic pyroGlu-Abeta variants, crucial in Alzheimer's disease. The data, published in Brain Communications, highlights ACI-24's robust immune response in non-human primates and mice, outperforming other tested vaccines. The company plans to advance ACI-24 into clinical development for Alzheimer's and Down syndrome-related Alzheimer's disease in 2022. AC Immune is positioned as a leader in developing active vaccines for neurodegenerative diseases.
AC Immune SA (NASDAQ: ACIU), a leader in precision medicine for neurodegenerative diseases, will participate in the SVB Leerink 11th Annual Global Healthcare Conference from February 14-18, 2022. CEO Prof. Andrea Pfeifer will engage in a fireside chat on February 16 at 8:00 am ET, discussing the company’s strategic plans and seven upcoming clinical readouts. The event will be available via webcast on their website. AC Immune is advancing a robust pipeline with ten therapeutic and three diagnostic candidates, focusing on diseases like Alzheimer’s and Parkinson’s.
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