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Achilles Therapeutics plc (NASDAQ: ACHL) is a clinical-stage biopharmaceutical company dedicated to developing next-generation, AI-powered precision T-cell therapies for the treatment of solid tumors. The company's innovative approach harnesses the immune system to target and destroy cancer cells by focusing on clonal neoantigens—unique protein markers present on all cancer cells but absent from healthy tissue.
Achilles Therapeutics employs advanced DNA sequencing and its proprietary PELEUS™ bioinformatics platform to identify these clonal neoantigens. This precision allows for the development of tailored T-cell-based product candidates aimed at these specific cancer markers. The company has two ongoing Phase I/IIa clinical trials: CHIRON for advanced non-small cell lung cancer (NSCLC) and THETIS for recurrent or metastatic melanoma.
Recent achievements include the progress in clinical trials, with additional clinical and translational science data expected in the fourth quarter of 2023. The strong cash position of $158.5 million supports operations into mid-2025. The company continues to refine its manufacturing processes, notably the VELOS™ platform, which has significantly improved T-cell doses.
A notable collaboration with Arcturus Therapeutics aims to combine Achilles' AI-driven technology with Arcturus' self-amplifying mRNA platform to develop personalized cancer vaccines. This research highlights Achilles' commitment to leveraging cutting-edge technologies for cancer treatment.
Achilles has also received significant patents and regulatory recognitions, including a US patent for its neoantigen immunogenicity prediction and an Innovation Passport from the UK MHRA, underlining its leadership in the bioinformatics and immunotherapy sectors.
Looking ahead, Achilles plans to report more clinical data in the first quarter of 2024 and continue its focus on optimizing its T-cell therapies and expanding its technological capabilities.
Achilles Therapeutics (NASDAQ: ACHL) leads a consortium awarded a €4 million ($4.2 million) grant from Horizon Europe to develop a first-in-class smart bioprocessing manufacturing platform for personalized cell therapies. This initiative aims to enhance manufacturing processes by incorporating advanced sensors and machine-learning controls. Of the total funding, approximately €1.4 million ($1.5 million) will go to Achilles. The project, named SMARTER, involves collaboration with leading institutions to advance cancer immunotherapy.
Achilles Therapeutics (NASDAQ: ACHL) announced the appointment of James Taylor as Chief Business Officer and Cassian Yee, MD to its Scientific Advisory Board, effective July 1, 2022. Taylor has over 25 years of experience in pharmaceutical and biotech deal-making, previously at Sosei Heptares and GSK. His focus will be on enhancing strategic partnerships for precision T cell therapies targeting solid tumors. Dr. Yee is a respected leader in immuno-oncology, contributing to the advancement of adoptive cellular therapy at MD Anderson Cancer Center.
Achilles Therapeutics (NASDAQ: ACHL), a clinical-stage biopharmaceutical company, has won the PING Innovation Award for its advancements in precision T cell therapies targeting clonal neoantigens. This award recognizes organizations making a significant impact in pharmaceuticals and life sciences. CEO Iraj Ali highlighted the company's commitment to developing individualized cancer treatments using AI-powered bioinformatics and unique patient data. Achilles is currently conducting two Phase I/IIa trials for advanced non-small cell lung cancer and melanoma, showcasing its innovative approach to cancer treatment.
Achilles Therapeutics (ACHL) announced key developments in its clinical trials and business operations as of May 10, 2022. They dosed the first patient in the CHIRON trial for advanced non-small cell lung cancer (NSCLC) with a higher-dose cNeT therapy and initiated enrollment for THETIS Cohort B, targeting metastatic melanoma. The company reported a robust cash balance of $236.9 million, sufficient to maintain operations into the second half of 2024. R&D expenses rose to $13 million, reflecting increased trial activities, while the net loss for Q1 2022 stood at $17.4 million.
Achilles Therapeutics (NASDAQ: ACHL) has announced significant progress in its clinical trials. The first patient received a personalized clonal neoantigen-reactive T cell (cNeT) in the CHIRON trial for advanced non-small cell lung cancer (NSCLC). Following a positive review by the Independent Data Safety Monitoring Committee, enrollment for THETIS Cohort B has also begun, testing cNeT with a PD-1 inhibitor for metastatic melanoma. Results from both trials are anticipated in the second half of 2022, highlighting the company's commitment to treating difficult cancers.
Achilles Therapeutics (NASDAQ: ACHL) announced the appointment of Bernhard Ehmer as a Non-Executive Director, enhancing the Board with his extensive experience in R&D and regulatory affairs. Previously, Ehmer held leadership roles in several biotech firms, including CEO of Biotest AG. The company also reported the resignation of Derek DiRocco from the Board on May 3, 2022. This transition comes as Achilles focuses on advancing its precision T cell therapies targeting cancer, supported by its proprietary PELEUS™ bioinformatics platform.
Achilles Therapeutics (NASDAQ: ACHL) announced its participation in two key conferences this May. The Bank of America 2022 Healthcare Conference will be held from May 9-13 in Las Vegas, where CEO Iraj Ali will speak on May 11 at 4:00 PM PT. Additionally, at the H.C. Wainwright Global Investment Conference from May 23-26 in Miami, VP Lee Stern will present on May 24 at 5:00 PM ET. Achilles focuses on developing precision T cell therapies for solid tumors, utilizing its proprietary PELEUS™ bioinformatics platform.
Achilles Therapeutics (NASDAQ: ACHL) announced a significant expansion in clinical manufacturing capabilities in the UK and US. The UK facility at the Cell & Gene Therapy Catapult has achieved GMP certification and will support ongoing Phase I/IIa trials with a new capacity for 600 doses of personalized cNeT therapies. The US partnership with the Center for Breakthrough Medicines will enhance supply chain operations with up to 200 doses. This expansion is expected to strengthen clinical operations and support future growth in treating advanced cancers.
Achilles Therapeutics (NASDAQ: ACHL) announced its participation in key conferences throughout April 2022 to discuss its innovative T cell therapies for solid tumors. On April 5, CEO Iraj Ali will join a panel at the Accelerating Bio-Innovation 2022 in Cambridge. Subsequently, he will present at the Needham Virtual Healthcare Conference on April 12, and attend the Kempen Life Sciences Conference on April 20 for investor meetings. A significant KOL webcast on April 14 will feature Professor Charles Swanton discussing the implications of the TRACERx study for personalized cancer treatment.
Achilles Therapeutics plc (NASDAQ: ACHL) announces a KOL webcast scheduled for April 14, 2022, at 10:30 AM ET. The event will feature Professor Charles Swanton, who will discuss the TRACERx study's role in identifying clonal neoantigens for personalized T cell therapies. The TRACERx study, with over 3,200 tumor samples from 800 lung cancer patients, is crucial for validating Achilles’ AI-powered PELEUS platform. The webcast will include presentations from key experts and a Q&A session moderated by Dr. Joseph Catanzaro.
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