Welcome to our dedicated page for Adicet Bio news (Ticker: ACET), a resource for investors and traders seeking the latest updates and insights on Adicet Bio stock.
Adicet Bio, Inc. (Nasdaq: ACET) is a clinical-stage biotechnology company engaged in the discovery and development of novel allogeneic gamma delta T cell therapies for the treatment of autoimmune diseases and cancer. Leveraging advanced immunotherapy techniques, Adicet Bio is pioneering the use of gamma delta T cells engineered with chimeric antigen receptors (CARs) and T cell receptors (TCRs) to create 'off-the-shelf' therapies aimed at providing durable and effective treatments for patients.
Core Products and Pipeline:
- ADI-001: A first-in-class allogeneic gamma delta T cell therapy expressing a CAR targeting CD20, currently in a Phase 1 clinical trial for relapsed or refractory aggressive B cell non-Hodgkin's lymphoma and autoimmune diseases such as lupus nephritis.
- ADI-270: An armored gamma delta CAR T cell product candidate targeting CD70, in preclinical development for renal cell carcinoma and other CD70+ solid and hematological malignancies.
Recent Achievements and Collaborations:
- FDA clearance of the Investigational New Drug (IND) application for ADI-001 in lupus nephritis and initiation of Phase 1 clinical trial expected in 2Q 2024.
- Strategic collaboration with Regeneron Pharmaceuticals, Inc. to develop next-generation engineered immune-cell therapeutics.
- Successful Series A financing round, raising $51 million led by Orbimed Partners, Orbimed Israel, and Novartis Ventures.
- Inducement awards granted to new employees as material inducements for employment, signifying ongoing growth and talent acquisition within the company.
- Presentation of promising preclinical data on ADI-270 at major scientific annual meetings, indicating robust anti-tumor activity and potential clinical benefits.
Financial Overview: Adicet Bio maintains a strong cash position with $247.6 million in cash and cash equivalents as of March 31, 2024, providing sufficient funding to support operations into the second half of 2026. The company continues to strategically invest in research and development, as well as in expanding its organizational capabilities.
Adicet Bio is at the forefront of innovation in the biotechnology space, striving to bring transformative therapies to patients with unmet medical needs. For more information, please visit Adicet Bio's official website.
Adicet Bio (Nasdaq: ACET) has opened enrollment for a Phase 1 clinical trial of ADI-001 in autoimmune diseases. The trial will focus on lupus nephritis (LN), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and anti-neutrophil cytoplasmic autoantibody (ANCA) associated vasculitis (AAV). Enrollment is currently open for LN patients, with SLE, SSc, and AAV enrollment expected to begin in Q4 2024.
The FDA has granted Fast Track Designation to ADI-001 for relapsed/refractory class III or IV LN treatment. The Phase 1 study consists of three arms, with patients receiving a single dose of ADI-001. Primary objectives include evaluating safety and tolerability, while secondary objectives focus on cellular kinetics, pharmacodynamics, autoantibody titers, and disease activity scores.
Adicet anticipates reporting preliminary clinical data for all indications in the first half of 2025.
Adicet Bio (Nasdaq: ACET) has announced promising clinical biomarker data for ADI-001 from the Phase 1 GLEAN trial, reinforcing its potential as a best-in-class allogeneic cell therapy for autoimmune diseases. Key findings include:
1. Robust tissue trafficking with high levels of ADI-001 in secondary lymphoid tissue
2. Significant chimeric antigen receptor (CAR) T cell activation
3. Complete CD19+ B cell depletion in secondary lymphoid tissue
The data shows superior exposure of ADI-001 in secondary lymphoid tissue compared to published third-party data for alpha-beta CAR T therapies. Adicet is advancing ADI-001 clinical programs in various autoimmune conditions and expects to report initial clinical data in the first half of 2025.
Adicet Bio (Nasdaq: ACET), a clinical stage biotechnology company focused on allogeneic gamma delta T cell therapies, has granted inducement awards to three new employees hired in August 2024. The awards include non-qualified stock options to purchase a total of 30,600 shares of Adicet's common stock at an exercise price of $1.46 per share.
The vesting schedule for these options is structured as follows: 25% of the shares will vest on the one-year anniversary of each recipient's start date, with the remaining 75% vesting in 36 monthly installments thereafter. Full vesting will occur on the fourth anniversary of the recipient's start date, subject to continued employment.
These awards were granted outside of Adicet's stockholder-approved equity incentive plans, under the company's 2022 Inducement Plan, in compliance with Nasdaq Listing Rule 5635(c)(4).
Adicet Bio (Nasdaq: ACET), a clinical-stage biotech company focused on allogeneic gamma delta T cell therapies for autoimmune diseases and cancer, has announced its participation in the H.C. Wainwright 26th Annual Global Investment Conference. The event is scheduled for September 9-11, 2024, in New York.
Chen Schor, President and CEO of Adicet Bio, will present on Tuesday, September 10, 2024, at 2:30 p.m. ET. Investors and interested parties can access the live audio webcast through the company's website. An archived replay will be available for 30 days after the presentation.
This conference provides Adicet Bio with an opportunity to showcase its innovative work in cell therapies and potentially attract investor interest. The presentation may offer insights into the company's progress, pipeline, and future plans in the rapidly evolving field of immunotherapy.
Adicet Bio (Nasdaq: ACET), a clinical-stage biotech company developing allogeneic gamma delta T cell therapies, has appointed Lloyd Klickstein, M.D., Ph.D. to its Board of Directors. Dr. Klickstein brings over two decades of leadership experience in biopharma and biomedical research, currently serving as CEO of Koslapp Therapeutics. His expertise in rheumatology, immunology, and drug development, along with his previous role as Chief Innovation Officer at Adicet, is expected to be valuable as the company advances its autoimmune programs and pipeline of gamma delta CAR T therapies. Dr. Klickstein's background includes co-founding Versanis Bio, leadership positions at Novartis, and academic roles at Brigham and Women's Hospital.
Adicet Bio (Nasdaq: ACET) reported Q2 2024 financial results and business updates. Key highlights include:
1. Expansion of ADI-001 clinical development to include SLE, SSc, and AAV, in addition to lupus nephritis.
2. FDA clearance for ADI-270 IND for relapsed/refractory renal cell carcinoma treatment.
3. Fast Track Designation granted for two product candidates.
4. Strong balance sheet with $224.1 million in cash as of June 30, 2024.
5. Net loss of $29.9 million ($0.33 per share) for Q2 2024.
6. R&D expenses decreased to $25.9 million, while G&A expenses increased slightly to $6.9 million.
7. Cash runway expected into the second half of 2026.
Adicet Bio (Nasdaq: ACET), a clinical stage biotechnology company focused on allogeneic gamma delta T cell therapies for autoimmune diseases and cancer, has announced its participation in two upcoming investor conferences in August 2024:
1. BTIG Virtual Biotechnology Conference (August 5-6): Adicet Bio will be available for one-on-one meetings.
2. Canaccord Genuity Global Growth Conference (August 13-14, Boston, MA): Chen Schor, President and CEO, will participate in a fireside chat on August 13 at 10:30am ET. A live audio webcast will be available on Adicet Bio's website, with a 30-day replay option.
These conferences provide opportunities for investors to gain insights into Adicet Bio's innovative therapies and future prospects.
Adicet Bio (Nasdaq: ACET), a clinical stage biotechnology company focused on allogeneic gamma delta T cell therapies, has granted inducement awards to four new employees hired in July 2024. The awards include non-qualified stock options to purchase a total of 70,400 shares of Adicet's common stock at an exercise price of $1.51 per share.
The options will vest over a four-year period, with 25% vesting on the one-year anniversary of each recipient's start date, followed by monthly installments over the next three years. These awards were granted outside of Adicet's stockholder-approved equity incentive plans, using the company's 2022 Inducement Plan, as authorized by the compensation committee in accordance with Nasdaq Listing Rule 5635(c)(4).
Adicet Bio (Nasdaq: ACET) has received FDA Fast Track Designation for its gamma delta T cell therapy, ADI-270, aimed at treating metastatic/advanced clear cell renal cell carcinoma (ccRCC). This designation intends to accelerate the development and review of ADI-270, which targets patients previously treated with an immune checkpoint inhibitor and a vascular endothelial growth factor inhibitor. CEO Chen Schor highlighted the significance of this milestone in addressing the most common form of kidney cancer and reaffirmed the company's commitment to rapid advancements in innovative treatments.
Adicet Bio announced inducement grants under Nasdaq Listing Rule 5635(c)(4) on June 28, 2024. The biotechnology company, focusing on allogeneic gamma delta T cell therapies for autoimmune diseases and cancer, granted stock options to two newly hired employees. These options, totaling 46,800 shares at an exercise price of $1.21 per share, will vest over four years, with one-fourth vesting after one year and the remainder vesting in equal monthly installments over the next three years. The awards, granted outside the company's stockholder-approved equity plans, were authorized by the compensation committee as a material inducement for the new hires.
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