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Adicet Bio, Inc. (Nasdaq: ACET) is a clinical-stage biotechnology company engaged in the discovery and development of novel allogeneic gamma delta T cell therapies for the treatment of autoimmune diseases and cancer. Leveraging advanced immunotherapy techniques, Adicet Bio is pioneering the use of gamma delta T cells engineered with chimeric antigen receptors (CARs) and T cell receptors (TCRs) to create 'off-the-shelf' therapies aimed at providing durable and effective treatments for patients.
Core Products and Pipeline:
- ADI-001: A first-in-class allogeneic gamma delta T cell therapy expressing a CAR targeting CD20, currently in a Phase 1 clinical trial for relapsed or refractory aggressive B cell non-Hodgkin's lymphoma and autoimmune diseases such as lupus nephritis.
- ADI-270: An armored gamma delta CAR T cell product candidate targeting CD70, in preclinical development for renal cell carcinoma and other CD70+ solid and hematological malignancies.
Recent Achievements and Collaborations:
- FDA clearance of the Investigational New Drug (IND) application for ADI-001 in lupus nephritis and initiation of Phase 1 clinical trial expected in 2Q 2024.
- Strategic collaboration with Regeneron Pharmaceuticals, Inc. to develop next-generation engineered immune-cell therapeutics.
- Successful Series A financing round, raising $51 million led by Orbimed Partners, Orbimed Israel, and Novartis Ventures.
- Inducement awards granted to new employees as material inducements for employment, signifying ongoing growth and talent acquisition within the company.
- Presentation of promising preclinical data on ADI-270 at major scientific annual meetings, indicating robust anti-tumor activity and potential clinical benefits.
Financial Overview: Adicet Bio maintains a strong cash position with $247.6 million in cash and cash equivalents as of March 31, 2024, providing sufficient funding to support operations into the second half of 2026. The company continues to strategically invest in research and development, as well as in expanding its organizational capabilities.
Adicet Bio is at the forefront of innovation in the biotechnology space, striving to bring transformative therapies to patients with unmet medical needs. For more information, please visit Adicet Bio's official website.
Adicet Bio, a clinical-stage biotechnology firm, has announced the granting of inducement awards on June 30, 2022, to ten new employees. The awards consist of non-qualified stock options for a total of 85,200 shares, priced at $14.60 each, reflecting the stock's closing price on that date. The vesting schedule spans four years, with a quarter vesting on the one-year anniversary of each employee’s start date, and the remainder vesting in monthly installments. This initiative follows the 2022 Inducement Plan authorized by the board in January 2022.
Adicet Bio, Inc. (Nasdaq: ACET) will participate in two significant investor conferences in June 2022. The first event is the Truist Securities Cell Therapy Symposium on June 28, where CEO Chen Schor will discuss key innovations in oncology at 11:30 A.M. ET. The second event is the Stifel 2022 Virtual Cell Therapy Summit from June 29-30, featuring a panel on new cell types on June 29 at 1:00 P.M. ET. Adicet focuses on allogeneic gamma delta T cell therapies for cancer, enhancing tumor targeting and immune response.
Adicet Bio announced positive interim results for ADI-001, showing a 75% overall response rate and a 100% complete response rate in patients with relapsed/refractory Non-Hodgkin’s Lymphoma as of May 31, 2022. The Phase 1 study results indicate a favorable safety profile with no instances of dose-limiting toxicities or severe adverse events. Notably, 50% of evaluable patients with at least six months of follow-up remain cancer-free. The company aims to identify a recommended Phase 2 dose in late 2022 and plans to initiate pivotal studies in early 2023.
Adicet Bio, Inc. (Nasdaq: ACET) announced the granting of inducement awards on May 31, 2022, as part of its 2022 Inducement Plan to four employees hired in May 2022. The awards consist of non-qualified stock options for a total of 100,800 shares with an exercise price of $11.82 per share, the closing price on the grant date. The vesting schedule allows for one-fourth of the options to vest annually, with complete vesting occurring over four years, contingent on continued employment.
Adicet Bio, Inc. (ACET) announced positive preliminary results from its Phase 1 trial of ADI-001 for relapsed/refractory B-cell Non-Hodgkin’s Lymphoma (NHL). As of
Adicet Bio, Inc. (Nasdaq: ACET), a clinical stage biotechnology company, announced participation in two investor conferences in May and June 2022. The H.C. Wainwright Global Investment Conference will occur from May 23-26, with an on-demand presentation available from May 24 at 7:00 A.M. ET. The Jefferies Healthcare Conference runs from June 8-10, featuring a presentation by CEO Chen Schor on June 10 at 8:30 A.M. ET. Live webcasts will be accessible via Adicet’s Investors section on their website.
Adicet Bio, Inc. (Nasdaq: ACET) announced its financial results for Q1 2022, reporting a net income of $4.6 million, compared to a net loss of $21.3 million in the same period last year. The company maintains a strong cash position with $277.9 million as of March 31, 2022. Significant operational highlights include the acceptance of interim data from the ADI-001 Phase 1 trial for oral presentation at the ASCO Annual Meeting and the granting of Fast Track Designation by the FDA for ADI-001 targeting Non-Hodgkin’s lymphoma. R&D expenses rose to $13.5 million.
Adicet Bio, Inc. (Nasdaq: ACET) presented promising preclinical data for ADI-001 during the ISCT Annual Meeting. The study highlighted ADI-001's strong in vitro and in vivo tumor growth inhibition across various human lymphoma cell lines, showcasing its adaptive and innate anti-tumor mechanisms. Notably, the non-gene-edited ADI-001 CAR T cells exhibited enhanced resilience against host-mediated clearance compared to gene-edited alternatives. ADI-001 is currently undergoing a Phase 1 clinical trial aimed at treating relapsed or refractory B-cell Non-Hodgkin’s lymphoma.
Adicet Bio, Inc. (NASDAQ: ACET), a clinical-stage biotechnology company, announced the granting of inducement awards on April 29, 2022, to four newly hired employees. The awards include non-qualified stock options to purchase a total of 62,000 shares at an exercise price of $14.74 per share, equal to the stock's closing price on that date. The vesting schedule allows for one-fourth of the shares to vest after one year, with the remainder vesting in monthly installments over three years. These awards were granted under Adicet's 2022 Inducement Plan, adopted in January 2022.
Adicet Bio, Inc. (NASDAQ: ACET) announced updated safety and efficacy data from the Phase 1 study of ADI-001 for treating relapsed or refractory B-cell Non-Hodgkin’s Lymphoma. This data will be presented at the American Society of Clinical Oncology (ASCO) Annual Meeting from June 3-7, 2022. The oral presentation, titled 'A phase 1 study of ADI-001: Anti-CD20 CAR-engineered allogeneic gamma delta T cells in adults with B-cell malignancies', is scheduled for June 6, 2022, at 8:00 AM CDT, featuring Sattva Neelapu, MD, from MD Anderson Cancer Center.
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