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Acumen Pharmaceuticals, Inc. - ABOS STOCK NEWS

Welcome to our dedicated page for Acumen Pharmaceuticals news (Ticker: ABOS), a resource for investors and traders seeking the latest updates and insights on Acumen Pharmaceuticals stock.

Acumen Pharmaceuticals, Inc. (NASDAQ: ABOS), headquartered in Charlottesville, VA with additional offices in Indianapolis, IN and Newton, MA, is a clinical-stage biopharmaceutical company innovating in the field of Alzheimer's disease (AD) and other neurodegenerative disorders. Acumen's core focus is on the development of novel, disease-modifying treatments by targeting toxic soluble amyloid-beta oligomers (AβOs), which are believed to be a primary underlying cause of AD. The company’s lead therapeutic candidate, sabirnetug (ACU193), is a humanized monoclonal antibody designed to selectively target these AβOs, thereby preventing synaptic dysfunction and neurodegeneration.

Acumen's scientific founders are pioneers in AβO research, contributing to decades of understanding in the field. This extensive research has culminated in the development of sabirnetug, which demonstrated positive topline results from the Phase 1 INTERCEPT-AD clinical trial. The trial showed that sabirnetug is well-tolerated, with a favorable safety profile, and demonstrated statistically significant, dose-related amyloid plaque reduction, validating its proof-of-mechanism.

Currently, Acumen is advancing sabirnetug into the Phase 2 ALTITUDE-AD trial, which aims to further evaluate its clinical efficacy and safety in early Alzheimer's disease. The company is also planning a Phase 1 study to explore a subcutaneous dosing option, enhancing patient accessibility and treatment convenience.

Acumen Pharmaceuticals remains committed to advancing its pioneering research into practical therapeutic solutions. The company's strategic partnerships, including a recent collaboration with Lonza for the manufacturing of sabirnetug, underscore its dedication to bringing effective treatments to market. With a strong financial footing, including $296.6 million in cash and marketable securities as of March 31, 2024, Acumen is well-positioned to support its clinical and operational activities into the first half of 2027.

Acumen’s mission is driven by the urgent need for safe and effective treatment options for Alzheimer's patients. Their work continues to be fueled by robust scientific insights and a commitment to improving the lives of those afflicted by AD.

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Acumen Pharmaceuticals will present deeper insights and new findings from its Phase 1 INTERCEPT-AD trial evaluating ACU193 at the CTAD conference. ACU193 demonstrated a compelling overall safety profile and potential clinical benefit for early AD. The presentation will include data on dose-related target engagement, amyloid plaque reduction, and ARIA levels observed with ACU193 administration. The company believes ACU193 may offer a differentiated, next-generation treatment for Alzheimer's disease.
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Acumen Pharmaceuticals to participate in panel discussion at Cantor Global Healthcare Conference
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Acumen Pharmaceuticals to present at H.C. Wainwright conference
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Acumen Pharmaceuticals, Inc. (NASDAQ: ABOS) reported positive Phase 1 trial results for ACU193, a potential antibody treatment for early Alzheimer's disease. The trial showed rapid reduction of amyloid plaque and near-maximal target engagement of toxic amyloid beta oligomers (AβOs). The company raised $122 million in net proceeds through a public follow-on offering. They have cash and marketable securities of $172.2 million, expected to support clinical activities until the second half of 2026. A Phase 2 study is expected to start in the first half of 2024.
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Acumen Pharmaceuticals, Inc. (NASDAQ: ABOS) announces the pricing of an upsized underwritten public offering of 16,774,193 shares of its common stock at $7.75 per share, expecting gross proceeds of approximately $130 million. The offering is expected to close on July 21, 2023. BofA Securities, Citigroup, and Stifel are acting as bookrunners for the public offering.
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Acumen Pharmaceuticals, Inc. (NASDAQ: ABOS) will host a conference call and webcast today to discuss the positive topline results from the Phase 1 INTERCEPT-AD trial of ACU193, a novel therapeutic for Alzheimer's disease. The webcast will feature members of Acumen's leadership team, as well as renowned experts in the field.
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Acumen Pharmaceuticals presents positive topline results from the Phase 1 INTERCEPT-AD trial of ACU193, a clinical-stage antibody therapy for Alzheimer's disease. Results show dose-related reduction in amyloid plaque and a compelling safety profile. ACU193 was generally well-tolerated with no drug-related serious adverse events. The company plans to discuss the results with regulators for the next phase of development.
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FAQ

What is the current stock price of Acumen Pharmaceuticals (ABOS)?

The current stock price of Acumen Pharmaceuticals (ABOS) is $1.85 as of December 20, 2024.

What is the market cap of Acumen Pharmaceuticals (ABOS)?

The market cap of Acumen Pharmaceuticals (ABOS) is approximately 106.8M.

What is Acumen Pharmaceuticals’ main focus?

Acumen Pharmaceuticals focuses on developing novel treatments targeting toxic soluble amyloid-beta oligomers (AβOs) for Alzheimer's disease and other neurodegenerative diseases.

What is sabirnetug (ACU193)?

Sabirnetug (ACU193) is a humanized monoclonal antibody developed by Acumen Pharmaceuticals to selectively target toxic soluble amyloid-beta oligomers, which are implicated in the pathology of Alzheimer's disease.

What were the results of the Phase 1 INTERCEPT-AD trial?

The Phase 1 INTERCEPT-AD trial demonstrated that sabirnetug was well-tolerated with a favorable safety profile. It showed statistically significant, dose-related amyloid plaque reduction, confirming proof-of-mechanism.

What is the Phase 2 ALTITUDE-AD trial?

The ALTITUDE-AD trial is a Phase 2, multi-center, randomized, double-blind, placebo-controlled clinical trial designed to evaluate the clinical efficacy and safety of sabirnetug in patients with early Alzheimer’s disease.

What are some recent achievements of Acumen Pharmaceuticals?

Recent achievements include the initiation of the Phase 2 ALTITUDE-AD trial, positive results from the Phase 1 INTERCEPT-AD trial, and a manufacturing collaboration with Lonza for sabirnetug.

What is Acumen’s financial condition?

As of March 31, 2024, Acumen Pharmaceuticals has $296.6 million in cash and marketable securities, supporting its clinical and operational activities into the first half of 2027.

Where is Acumen Pharmaceuticals headquartered?

Acumen Pharmaceuticals is headquartered in Charlottesville, VA, with additional offices in Indianapolis, IN, and Newton, MA.

What is the significance of targeting amyloid-beta oligomers (AβOs)?

Targeting AβOs is significant because they are believed to play a critical role in the early and persistent pathology of Alzheimer’s disease, leading to synaptic dysfunction and neurodegeneration.

What future plans does Acumen Pharmaceuticals have for sabirnetug?

Future plans include advancing sabirnetug in the Phase 2 ALTITUDE-AD trial and initiating a Phase 1 study to support a subcutaneous dosing option to enhance patient accessibility.

How can investors get more information about Acumen Pharmaceuticals?

Investors can obtain more information by visiting Acumen Pharmaceuticals' official website at www.acumenpharm.com and accessing the 'Investors' tab for updates and resources.

Acumen Pharmaceuticals, Inc.

Nasdaq:ABOS

ABOS Rankings

ABOS Stock Data

106.78M
53.31M
11.24%
78.5%
2.44%
Biotechnology
Biological Products, (no Disgnostic Substances)
Link
United States of America
CHARLOTTESVILLE