AbCellera Announces Two T-Cell Engager Presentations at SITC 2023
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“We have made significant progress on the application of our T-cell engager platform since we presented data at SITC in 2022,” said Bo Barnhart, Ph.D., VP, Translational Research at AbCellera. “We’re looking forward to presenting two posters this year demonstrating how key insights into CD3 T-cell engager biology help us to execute on our programs for various tumor targets, including a challenging peptide-MHC target.”
Details on AbCellera’s poster presentations at SITC are as follows:
Title: A rational approach for selecting CD3-binding antibodies for T-cell engager development
Abstract Number: 1367
Date and Time: Friday, November 3 from 9:00 a.m. to 7:00 p.m. PDT
Location:
Title: Targeting intracellular tumor antigens to fight cancer: Discovery and development of functional and specific T-cell engagers against a MAGE-A4 pMHC
Abstract Number: 1395
Date and Time: Friday, November 3 from 9:00 a.m. to 7:00 p.m. PDT
Location:
About T-Cell Engagers
CD3 T-cell engagers are bispecific antibodies that guide the immune system to find and eliminate cancer cells by binding both cancer-killing T cells and tumor targets at the same time. Developing effective T-cell engagers requires two parental antibodies—a CD3-binding arm that fine-tunes T-cell activation and a tumor-binding arm with high specificity for cancer cells. The small number of available CD3-binding antibodies that can effectively fine-tune T-cell responses has been a barrier to T-cell engager development. To address this barrier, AbCellera developed a complete T-cell engager platform that includes fully human, developable CD3-binding antibodies with unique binding and functional properties. By combining these antibodies with OrthoMabTM, its clinically validated multispecific engineering platform, and its antibody discovery and development engine, AbCellera’s T-cell engager platform is designed to bring new cancer medicines to the clinic faster.
About AbCellera Biologics Inc.
AbCellera is breaking the barriers of conventional antibody drug discovery to bring better medicines to patients, sooner. AbCellera’s engine integrates expert teams, technology, and facilities with the data science and automation needed to propel antibody-based medicines from target to clinic in nearly every therapeutic area with precision and speed. AbCellera provides innovative biotechs and leading pharmaceutical companies with a competitive advantage that empowers them to move quickly, reduce cost, and tackle the toughest problems in drug development. For more information, please visit www.abcellera.com.
AbCellera Forward-Looking Statements
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Inquiries
Media: Jessica Yingling, Ph.D.; media@abcellera.com, +1(236)521-6774
Business Development: Murray McCutcheon, Ph.D.; bd@abcellera.com, +1(604)559-9005
Investor Relations: Josephine Hellschlienger, Ph.D.; ir@abcellera.com, +1(778)729-9116
Source: AbCellera Biologics Inc.
