AbCellera Announces Four Presentations on T-Cell Engagers at AACR 2024
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With its T-cell engager platform, AbCellera is expanding therapeutic opportunities for this modality by generating molecules with the potential for improved efficacy and safety profiles for solid tumors and challenging targets such as peptide-MHCs.
AbCellera will present four posters at AACR that demonstrate how it is leveraging its platform to develop T-cell engagers with potent tumor-cell killing and low cytokine release for multiple cancer targets. Using data integrated from across these programs, AbCellera will present new insights into T-cell engager function. In addition, AbCellera will present data on novel CD28-binding antibodies that can be used to optimize T-cell engagers, particularly for solid tumors that are difficult to treat using current immunotherapies.
Details on AbCellera’s poster presentations at AACR are as follows:
Title: Functional and specific T-cell engagers against a peptide-MHC tumor target
Abstract Number: 2373
Session: Antibodies 1
Date and Time: Monday, April 8, 2024, 9:00 a.m. to 12:30 p.m. PT
Location: Section 38, Board 19
Title: Diverse CD28-binding IgG and heavy chain-only antibodies for T-cell engager development
Abstract Number: 1859
Session: Antibody-Based Technologies and New Inhibitors
Date and Time: Monday, April 8, 2024, 9:00 a.m. to 12:30 p.m. PT
Location: Section 22, Board 3
Title: Target-dependent considerations for the design of bispecific T-cell engagers
Abstract Number: 1868
Session: Antibody-Based Technologies and New Inhibitors
Date and Time: Monday, April 8, 2024, 9:00 a.m. to 12:30 p.m. PT
Location: Section 22, Board 12
Title: Development of PSMA x CD3 T-cell engagers using an integrated, functional approach
Abstract Number: 6359
Session: Antibodies 2
Date and Time: Tuesday, April 9, 2024, 1:30 p.m. to 5:00 p.m. PT
Location: Section 41, Board 20
About AbCellera’s T-Cell Engager Platform
CD3 T-cell engagers are bispecific antibodies that guide the immune system to find and eliminate cancer cells by binding both cancer-killing T cells and tumor targets at the same time. Developing effective T-cell engagers requires two parental antibodies—a CD3-binding arm that fine-tunes T-cell activation and a tumor-binding arm with high specificity for cancer cells. The small number of available CD3-binding antibodies that can effectively fine-tune T-cell responses has been a barrier to T-cell engager development. To address this barrier, AbCellera developed a complete T-cell engager platform that includes fully human, developable CD3-binding antibodies with unique binding and functional properties. By combining these antibodies with OrthoMab™, its clinically validated multispecific engineering platform, and its antibody discovery and development engine, AbCellera’s T-cell engager platform is designed to bring new cancer medicines to the clinic faster.
About AbCellera Biologics Inc.
AbCellera is breaking the barriers of conventional antibody drug discovery to bring better medicines to patients, sooner. AbCellera’s engine integrates expert teams, technology, and facilities with the data science and automation needed to propel antibody-based medicines from target to clinic in nearly every therapeutic area with precision and speed. AbCellera provides innovative biotechs and leading pharmaceutical companies with a competitive advantage that empowers them to move quickly, reduce cost, and tackle the toughest problems in drug development. For more information, please visit www.abcellera.com.
AbCellera Forward-Looking Statements
This press release contains forward-looking statements, including statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The forward-looking statements are based on management’s current beliefs and assumptions and on information currently available to management. All statements contained in this release other than statements of historical fact are forward-looking statements, including statements regarding our ability to develop, commercialize, and achieve market acceptance of our current and planned products and services, our research and development efforts, and other matters regarding our business strategies, use of capital, results of operations and financial position, and plans and objectives for future operations.
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Inquiries
Media: Kathleen Reid; media@abcellera.com, +1(604)724-1242
Business Development: Murray McCutcheon, Ph.D.; bd@abcellera.com, +1(604)559-9005
Investor Relations: Melanie Solomon; ir@abcellera.com, +1(778)729-9116
Source: AbCellera Biologics Inc.
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