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Aadi Bioscience Announces Poster Presentations at the 2024 American Society of Clinical Oncology (ASCO) Genitourinary (GU) Cancers Symposium

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Aadi Bioscience, Inc. (NASDAQ: AADI) presented poster presentations at the 2024 American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium, highlighting the analysis of inactivating alterations in TSC1 and TSC2 in advanced genitourinary (GU) cancers from a real-world patient population in the Foundation Medicine genomic database. Key findings include the prevalence of TSC1 and/or TSC2 inactivating alterations in patients with bladder, kidney, and prostate cancer, as well as the enrollment of patients in the PRECISION 1 study for solid tumors harboring these alterations.
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Real-world genomic analysis highlights unmet medical need in GU cancer patients with TSC1/2 inactivating alterations

LOS ANGELES, Jan. 26, 2024 /PRNewswire/ -- Aadi Bioscience, Inc. (NASDAQ: AADI), a biopharmaceutical company focused on developing and commercializing precision therapies for patients with mTOR pathway alterations, today announced poster presentations at the 2024 American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium, taking place January 25-27, 2024, in San Francisco, CA.

Abstract and poster presentation details are below:

Title: "Analysis of inactivating alterations in TSC1 and TSC2 in advanced genitourinary (GU) cancers from a real-world patient population in the Foundation Medicine genomic database"
Session Title: Poster Session B: Urothelial Carcinoma
Date/Time: January 26, 2024 – 11:30 – 1:00 pm; 5:45 – 6:45 pm PST
Presenting Author: Gopa Iyer, MD
Key Findings:

  • In a large real-world database of patients with advanced cancer, 1,828 (4.0%) of the 46,068 patients with GU cancers had at least one inactivating alteration in TSC1 or TSC2
  • TSC1 and/or TSC2 inactivating alterations were present in 9.2% of patients with bladder cancer, 6.4% of patients with kidney cancer, and 0.6% of patients with prostate cancer
  • GU cancers with TSC1 and/or TSC2 inactivating alterations were frequently microsatellite stable and of low tumor mutational burden (TMB)
  • The PRECISION 1 study (NCT05103358) is currently enrolling patients with solid tumors harboring TSC1 and/or TSC2 inactivating alterations

Aadi is also presenting an encore Trials-in-Progress (TiP) poster from the ongoing PRECISION 1 study.

Title: "PRECISION 1: A phase 2, multicenter, open-label tumor-agnostic trial of nab-sirolimus for malignant solid tumors harboring pathogenic inactivating alterations in TSC1 and TSC2"
Session Title: Trials in Progress Poster Session C: Renal Cell Cancer: Adrenal, Penile, Urethral and Testicular Cancers
Date/Time: January 27, 2024 – 7:00 – 8:00 am; 11:30 am – 1:00 pm PST
Presenting Author: Gopa Iyer, MD

More information can be found on the ASCO GU meeting website.

About Aadi Bioscience, Inc.

Aadi is a commercial-stage biopharmaceutical company focused on precision therapies for genetically defined cancers to bring transformational therapies to cancer patients with mTOR pathway driver alterations. Aadi received FDA approval and has commercialized FYARRO® for the treatment of adult patients with locally advanced unresectable or metastatic malignant perivascular epithelioid cell tumor (PEComa).

Aadi has also initiated PRECISION1, a Phase 2 tumor-agnostic registration-intended trial in mTOR inhibitor-naïve malignant solid tumors harboring TSC1 or TSC2 inactivating alterations. More information on the Company's development pipeline is available on the Aadi website at www.aadibio.com and connect with us on Twitter and LinkedIn.

Contact:
Marcy Graham
IR@aadibio.com

(PRNewsfoto/Aadi Bioscience)

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SOURCE Aadi Bioscience

FAQ

What is the focus of Aadi Bioscience's poster presentations at the 2024 ASCO Genitourinary Cancers Symposium?

Aadi Bioscience presented poster presentations focusing on the analysis of inactivating alterations in TSC1 and TSC2 in advanced genitourinary (GU) cancers from a real-world patient population in the Foundation Medicine genomic database.

What are the key findings of the analysis presented by Aadi Bioscience?

The key findings include the prevalence of TSC1 and/or TSC2 inactivating alterations in patients with bladder, kidney, and prostate cancer, as well as the enrollment of patients in the PRECISION 1 study for solid tumors harboring these alterations.

What is the title of the ongoing study presented by Aadi Bioscience at the ASCO Genitourinary Cancers Symposium?

The ongoing study presented by Aadi Bioscience is titled 'PRECISION 1: A phase 2, multicenter, open-label tumor-agnostic trial of nab-sirolimus for malignant solid tumors harboring pathogenic inactivating alterations in TSC1 and TSC2'.

Who is the presenting author of the poster presentations?

The presenting author of the poster presentations is Gopa Iyer, MD.

Aadi Bioscience, Inc.

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