Agilent Announces NGS Assay for Comprehensive Genomic Profiling (CGP) for Advancing Precision Oncology

Rhea-AI Summary

Agilent Technologies (NYSE: A) has launched the SureSelect Cancer CGP Assay, aimed at somatic variant profiling for a wide range of solid tumors. This innovative assay features a panel of 679 globally curated genes and supports various biomarkers, including tumor mutational burden (TMB) and microsatellite instability (MSI). With an efficient workflow allowing low sample input as low as 10 ng, this assay enhances accessibility for clinical researchers. The assay can be automated, reducing hands-on time from several hours to just 15 minutes. Agilent's focus on precision oncology is underscored by this release and its recent acquisition of Avida Biomed. The company generated $6.85 billion in revenue in fiscal 2022, emphasizing its significant market presence.

Positive

• Launch of the SureSelect Cancer CGP Assay for somatic variant profiling.
• The assay covers 679 globally curated genes, enhancing tumor profiling capabilities.
• Supports critical biomarkers such as TMB and MSI, aiding cancer therapeutic research.
• Workflow efficiency improved, with automation reducing hands-on time to 15 minutes.
• Allows profiling of low-input samples (as low as 10 ng), broadening research opportunities.
• Recent acquisition of Avida Biomed aligns with expanding oncology portfolio.

Negative

• None.

SureSelect Cancer CGP assay expands the number of biomarkers for solid tumor profiling with a fast and highly efficient workflow

SANTA CLARA, Calif.--(BUSINESS WIRE)-- Agilent Technologies Inc. (NYSE: A) today announced the launch of the Agilent SureSelect Cancer CGP Assay designed for somatic variant profiling for a broad range of solid tumor types. The pan-cancer assay design is based on an NGS panel comprising 679 genes globally curated from leading cancer databases and in partnership with key clinical cancer researchers. The assay workflow is efficient, automatable, and flexible, making tumor molecular profiling more accessible to the broad clinical research community.

The biomarkers include key classes of somatic variants (SNVs, CNVs, indels, translocations, de novo gene fusions), along with the immuno-oncology biomarkers TMB (tumor mutational burden), and MSI (microsatellite instability) to aid clinical and translational researchers in investigating potential cancer therapeutics. Based on Agilent’s industry-leading library prep and target enrichment chemistry, this high-performance assay provides up-to-date, globally curated biomarker content for comprehensive molecular profiling of solid tumors, supports as low as 10 ng of input, and incorporates walkaway automation to improve lab efficiency and productivity. The workflow incorporates flexible data analysis options, including Alissa Interpret for tertiary analysis and reporting, customer bioinformatics pipelines, and third-party software.

“We’re pleased to commercialize the SureSelect Cancer CGP assay, which leverages our SureSelect chemistry that can accommodate a low amount of starting material so that scientists can profile more quantity-limited samples,” explained Ronda Allen, Ph.D., vice president and general manager, Genomics Division at Agilent. “Library preparation and target enrichment can be automated either on the benchtop Magnis NGS prep system, which will markedly improve workflow efficiency, reducing the hands-on time from hours to only 15 minutes, or on the Bravo NGS workstation, for scaling up to 96 samples per run.”

Dr. Alistair Ritchie, sequencing laboratory manager at Glasgow Precision Oncology Laboratory (GPOL), shared his experience with the assay. “The comprehensive coverage of the CGP assay means we can batch DNA from any solid tumor on a single run to streamline our workflow,” he said. “Our team has come to rely on the Agilent SureSelect XT HS2 method for all our target enrichment assays. We have never used a method that gives us such reproducible results with such a low input amount.”

“The release of the SureSelect Cancer CGP assay, as well as the recent acquisition of Avida Biomed, demonstrates Agilent’s commitment to developing high-performing NGS tools for an expanding oncology portfolio, accelerating the advancement of precision oncology. We are proud to partner with clinical researchers and leading cancer centers, such as Glasgow Precision Oncology Laboratory,” added Allen.

Agilent is an industry leader with a continuously growing portfolio of world-class chemistries and technologies and has an established presence as a global provider and partner for biomarker analysis and companion diagnostics across the precision oncology sector.

About Agilent Technologies

Agilent Technologies Inc. (NYSE: A) is a global leader in the life sciences, diagnostics, and applied chemical markets, delivering insight and innovation that help our customers bring great science to life. Agilent’s full range of solutions includes instruments, software, services, and expertise that provide trusted answers to our customers' most challenging questions. The company generated revenue of $6.85 billion in fiscal 2022 and employs 18,000 people worldwide. Information about Agilent is available at www.agilent.com. To receive the latest Agilent news, please subscribe to the Agilent Newsroom. Follow Agilent on LinkedIn and Facebook.

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Media Contact

Naomi Goumillout

Agilent Technologies

+1.978.314.1862

naomi.goumillout@agilent.com

Source: Agilent Technologies Inc.

FAQ

What is the Agilent SureSelect Cancer CGP Assay?

The SureSelect Cancer CGP Assay is a new assay from Agilent designed for somatic variant profiling across a variety of solid tumor types.

How many genes does the SureSelect Cancer CGP Assay cover?

The assay covers 679 globally curated genes.

What are the key biomarkers included in the SureSelect Cancer CGP Assay?

The assay includes biomarkers such as tumor mutational burden (TMB) and microsatellite instability (MSI).

How does the SureSelect Cancer CGP Assay improve workflow efficiency?

The assay allows automation, reducing hands-on time from several hours to just 15 minutes.

What was Agilent's revenue in fiscal 2022?

Agilent generated a revenue of $6.85 billion in fiscal 2022.