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Molecular Partners (MOLN) reported its Q1 2024 results, highlighting advancements in its clinical pipeline.
Key updates include the ongoing Phase 1 trial of MP0533, with dose escalation progressing smoothly and showing promising safety and anti-tumor activity. The Radio-DARPin Therapy platform is advancing with IND-enabling studies set for 2024, and preclinical data to be presented at upcoming conferences.
The company also provided updates on its Switch-DARPin Platform and MP0317 program, both showing progress towards key milestones.
Financially, Molecular Partners has CHF 174.1 million in cash, with no debt, funding into 2026. Operating expenses are expected to be CHF 70-80 million for 2024.
Molecular Partners announced the publication of preclinical data supporting MP0533's unique mechanism of action for treating acute myeloid leukemia in Cancer Immunology Research. The data demonstrates preferential killing of AML cells while sparing healthy cells, T-cell activation, tumor regression, and cytokine release without systemic adverse effects. The publication supports the rationale for the clinical development of MP0533 as monotherapy and in combination with other drugs. The ongoing Phase 1/2a clinical study is progressing well, currently dosing patients in cohort 7.
